What model of audio interface do you use?
Focusright scarlet 414,but thorleif figured out that I had the thru on - and that is why I could not get rid of the guitar sound
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I am not familiar with this term for audio but I suppose you are talking about Direct Monitoring?
That is the thing I never touch, it is always turned to USB so I never have that issue ! 
what is turned to USB? Your interface? if so, What kind of interface?
I find myself in possession of probably the three best Midi Instruments; MG three, triple play, and ROR wired guitar. I need to learn MG three better to be able to truly compare the three
I was referring to your scarlett: when the monitor knob is not set fully clockwise âyou are hearing the signal before it reaches the softwareâ (quotation from the scarlett instructions for use).
When the monitor knob is set fully clockwise you are hearing the signal coming from the software via USB.
The Scarlett has no labels written around this knob, youâll find written on other interfaces, direct/usb, direct/daw, dry/wet, etc.