Studio One Low Latency Mode not working

Hello, I haven’t been able to get Mid Guitar 2 to work with Studio One 5’s low latency mode i.e. setting buffer protection on maximum, then with Studio One creating a separate low latency path for things that are being monitored (with the green z lit up).
If I turn off the low latency mode, then it works. Is this something that can be fixed on the Midi Guitar 2 side, Studio One side, or do both programs need to be modified somehow?